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Its success helped validate obesity as a chronic disease market rather than a lifestyle-adjacent category

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However it should be noted that the overall and off-label use of GLP-1R agonists in 2023 are likely underestimated in the published study, as it doesnt include the recently approved member of this group, tirzepatide (Mounjaro), which induces even greater weight loss than Ozempic

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65 Mice homozygous for the physiologically important AKT substrate TBC1D4 Thr 649 knock-in exhibit impaired insulin-stimulated myocellular GLUT4 translocation and induction of glucose intolerance