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Everett Koop, the Surgeon General from 1981 to 1989 took a strong stance on the health hazards of tobacco
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Nicotine activates an innate, anti-inflammatory pathway via the macrophage 7-nicotinic acetylcholine receptor, and interruption of this pathway exacerbates nicotine-associated inflammation and insulin resistance in mice [116], which would be consistent with a co-existing anti-inflammatory effect of nicotine on obesity-related inflammation [117]
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Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice
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