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In April, Eli Lilly announced positive topline results of a phase 3 clinical trial showing that tirzepatide significantly reduced the AHI compared with placebo

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GeroScience (2026)

GLP-1 Effects on Kidney Function and Hydration GLP-1 receptor agonists slow stomach emptying and reduce appetite signals, leading many patients to drink less fluid throughout the day simply because thirst signals diminish

It is best to wait until the escalation ends and stomach symptoms resolve

Overall tolerability of the treatment was good, with the most common side effect being nausea, particularly during treatment initiation or dose adjustments, while diarrhea was reported by 5% of patients, which was dose-dependent and easily managed