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The NHIS recommends that all individuals aged 40 years and employers of all age among the insured, undergo a general health screening at least every two years 14 , which includes a standard questionnaire of past medical history, current medications, and lifestyle behaviors (smoking, drinking, and physical activity), anthropometric measurements (height, weight, body mass index, and blood pressure), and laboratory tests

13,15 More research is needed on the comparative efficacy among current treatment options

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Sex-related estrogen receptors have been implicated in the formation and occurrence of LC, and estrogen receptor beta has been demonstrated to protect LC cells by controlling indicators of the epithelialmesenchymal transition, including nuclear betacatenin activation and E-cadherin downregulation 30,31

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