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Local injection site reactions are a normal immune response to a foreign substance entering the skin and do not indicate true allergy

Lactic acidosis has been reported in approximately 32% of metformin overdose cases [see WARNINGS AND PRECAUTIONS ]

Because it is injected and acts systemically, traces of the drug and its metabolites can appear in maternal circulation and theoretically reach breast tissue

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Brain: A Journal of Neurology, 127(Pt 12), 25722583

While it doesn't predict exact duration, it helps your provider estimate your relapse vulnerability and tailor your long-term strategy accordingly