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Freeze-thaw cycling can disrupt the copper coordination sphere as well as degrade the peptide backbones, so single-use aliquots are preferable to repeatedly accessing one stock

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However, the available studies emphasise that much of the data comes from preclinical models, cellular studies and older publications in the area of experimental gerontology, so interpretation of the results should take into account the experimental nature of this substance and the limited scale of modern, high-quality clinical trials

& Marasco, D