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Although DPP4 inhibitors are now widely used for glycemic control, many debates are ongoing about their exact mode of action and their beneficial effects on pancreatic cells

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Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer

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Main Text Glucagon-like peptide-1 (GLP-1), a neuroendocrine hormone, is derived from a proglucagon precursor ( 1 ) and secreted by intestinal enteroendocrine L cells in response to nutrient intake ( 2 ), predominantly in the form of GLP-1(7-36) amide (henceforth GLP-1) ( 3 )

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California adds a second set of problems most people dont see coming

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Feeling frustrated by a lack of time to work toward your fitness goals

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This suggests that GLP-1 therapy may create lasting physiologic changes, even when the medication is temporarily stopped

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