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Smoking can harm blood vessels and ED frequently results from inadequate arterial blood supply to the penis

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Furthermore, nicotine is not only significantly decreasing the testicular activity of androgenic enzymes including testicular steroidogenic acute regulatory (StAR) protein resulting in decreased intratesticular and plasma testosterone and gonadotropin concentrations, but also reduced the testicular levels of glutathione, activities of antioxidative enzymes and mitochondrial membrane potential in testicular cells