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[Pg 64]All cigar leaf tobacco is sun-cured, and as a general rule pipe smoking and chewing tobacco are cured by artificial heat
While not entirely safe, they eliminate the addictive element of nicotine, making them a preferred choice for those seeking the healthiest thing to smoke
Direct application of a variety of E-liquids to human Saos-2 and MG-63 cells, (another osteoblast-like cell line, derived from a human osteosarcoma) at concentrations up to 4%, delivering a nicotine dose of up to 1 mg/ml (falling within a theoretical physiological exposure range of 1-3 mg of nicotine per cigarette) reduced cellular viability, independent of nicotine [41]
doi: 10.2307/2531248 52
Severe nicotine poisoning from ingestion can cause nausea, vomiting and arrhythmias, and can even progress to seizures, respiratory depression and death