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Minor bloodbrain barrier disruption was also noted in the substantia nigra, white matter, and posterior cortical regions of patients with Parkinsons disease[49]

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It is the appetite-stimulating effect that dominates its perceived clinical profile and makes it a valuable tool for studying the orexigenic regulation of the GH-ghrelin axis

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It is sometimes used off-label for purported anti-aging purposes, body composition improvement, and metabolic enhancement, though it lacks FDA approval for these indications

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