MET is synthesized as a single-chain precursor, which is then cleaved into an , heterodimer by a protease of the furin family in the Golgi apparatus (Komada et al., 1993)
Importantly, there are heterogenous populations of GABA neurons in the VTA, including GABA interneurons
Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe gastrointestinal disease, or active pancreatitis
Ozempic was approved for type 2-diabetes in 2017, but it became increasingly common for doctors to prescribe it to obese patients off-label as a treatment to control weight
This is why B12 levels tend to deplete quickly and need to be maintained on a regular basis
Since the 2025 NJ Health Mandate, many Horizon and Aetna plans in Morristown provide coverage if your BMI is over 30 or if you have a weight-related comorbidity