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A similar phenotype has been reported in macrophages, where cigarette smoke can adversely affect cholesterol transport through an ABCA1-dependent mechanism

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This was controversial

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Conclusions: The increased risk of COPD due to childhood smoking was independent of cigarette pack years, smoking duration, secondhand smoke exposure, and current smoking

Townsend, Historic Preservationist: For a generation of Cherokees that destruction was all they knew