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Choosing to use them is essentially a reasoned bet that findings in animal models will translate to humans plausible based on the underlying mechanisms, but not yet proven
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Berberine also inhibits the activation of MAPK and NF-B signaling pathways that stimulate proinflammatory cytokine production in both colonic macrophages and epithelial cells from DSS-treated mice (122)
JCI Insight 3 , e123047 (2018)
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