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Spontaneous rupture of large arteries was not observed at all and, in particular, neither in the 6 patients with the COL1A1 p.(Arg312Cys) missense variant nor in 2 individuals with different COL5A1 glycine substitutions at the C-terminal domain (Additional Table 1), which represent variants previously associated with a possible higher risk of vascular events [16]
Persistent fatigue, irritability, difficulty concentrating, and mood disturbances are commonly associated with insomnia
Little does her character, Gertie, know the true horror of what Gemma has done
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