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Acute pancreatitis can also be caused by: Surgery, such as endoscopic retrograde cholangiopancreatography (ERCP) a procedure to take out gallstones and check your pancreatic ducts High triglycerides (blood fats) over 1,000 milligrams per deciliter (mg/dL) Infections Autoimmune and vascular diseases Metabolic disorders such as high calcium (hypercalcemia) Cysts, tumors, or other pancreatic problems For 15 out of every 100 people with acute pancreatitis, the cause is unknown