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With over 50 million individuals currently affected by dementia worldwidea number projected to double by 2050there is a critical need for novel, mechanism-based interventions, particularly in the absence of curative therapies (Sexton et al., 2022)

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Additionally, inhibition of CD38 in the AD mouse model restored NAD + levels, decreased mitochondrial ROS production and plaque depositions in the hippocampus and cortex, and improved cognitive abilities 158

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