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However, the number of smokers worldwide has increased from 721 million in 1980 to 967 million in 2012, and the number of cigarettes smoked increased from 4 } : CS1 maint: multiple names: authors list (link) "Surgeon General's ReportWomen and Smoking"

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23 Importantly, our results identify GPR15 as a crucial mediator that transduces environmental signals from cigarette smoke to influence immune responses in specific IBD models