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As discussed previously, these receptors bind the nicotine, resulting in the cascade of events that leads to nicotine addiction

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doi:10.2105/ajph.92.6.917

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8 In a 2016 Cochrane Review citing evidence from two randomized controlled trials totaling 662 participants, those using nicotine-containing e-cigarettes were more likely to achieve six months of abstinence from conventional cigarettes compared with those assigned to non-nicotine-containing e-cigarettes (risk ratio 2.29, 95% CI 1.054.96)