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[142] From 1965 to 2006, rates of smoking in the United States have declined from 42% to 20.8%

A large majority of such studies were also not designed to infer causality

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Thus, while e-cigs may decrease the use of conventional cigarettes in adults with an existing smoking history, the prevalence of e-cig usage is greater in adolescent asthmatics relative to non-asthmatics, which is of concern

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