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Acetylcholine is one of the most important neurotransmitters necessary for memory, learning, concentration and muscle movement.*

This technique is easy and rapid to perform but the disadvantages are that it violates the articular cartilage and far posterior condylar lesions may be difficult to access with this approach (Figure 4)

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Evening administration operates through a different pathway

Upregulation of Antioxidant and Repair Genes: It increases the expression of genes responsible for DNA repair, antioxidant production (e.g., superoxide dismutase), and the synthesis of structural proteins like collagen and elastin