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Most do not survive digestion in a form that produces the effect promised on the label

Int Rev Neurobiol 349371 El Yacoubi MLC, Parmentier M, Bertorelli R, Ongini E, Costentin J, Vaugeois JM (2001) Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice

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