why does semaglutide cause depression Doctors and patients across social media are reporting a kind of emotional flattening while on GLP-1 drugs. Anecdotally, physicians describe meaningful mental health gains — greater self-esteem Glucagon-like peptide-1 medicines in neurological

However, several indirect mechanisms may influence B12 levels in patients using these treatments

Some patients report noticeable cosmetic changes after 2 to 4 months of consistent use

Feb 23, 2026 Some people swear by injectable GLP-1 medications for appetite control and metabolic health

160,161 Their hypothesis suggested that available fatty acids promote fatty acid oxidation and cause the accumulation of mitochondrial acetyl coenzyme A (CoA) and NADH, with subsequent inactivation of pyruvate dehydrogenase

The results follow previous research* from the same international team finding that weekly injections of semaglutide were linked to a 20% reduction in major adverse cardiac events (MACE) such as heart attacks and strokes for people with obesity or who were overweight and had cardiovascular disease

Am J Resp Critical Care Medicine, 2017