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Cigarette smoke impairs endothelial function due to vagal input from the airway rather than a specific smoke constituent The ability of blood vessels to widen was examined in the rat study before and after exposure to smoke from four types of classic combustible cigarettes: conventional nicotine, reduced nicotine, conventional nicotine with added menthol, and reduced nicotine with added menthol

Even people who smoke less than five cigarettes a day can have early symptoms of cardiovascular disease

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Allen et al., 1983)

I think it's an adequate price to pay for reduced health hazards