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separate cyclosporine by 3 hours and levothyroxine by 4 hours from orlistat Defined endpoints for assessing whether combination provides meaningful benefit Safety parameters including triggers for discontinuation Patients should be counseled to report severe or persistent gastrointestinal symptoms, signs of malnutrition, jaundice, dark urine, or severe abdominal pain

However, hypersensitivity or allergic reactions to current medications, as well as defects in certain BBSome genes that disrupt NPY2 receptor trafficking to primary cilia, may limit the effectiveness of these therapies in specific BBS cases (47)

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Similarly, symptoms such as difficulty breathing, significant swelling, or a rash spreading beyond the injection site require immediate medical attention

Maintained for the next 3 years

[ [PMID: 33667417] et al