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Pathophysiological mechanisms by which testosterone deficiency might impair glucose metabolism in men include reduced insulin receptor expression and intracellular insulin signaling, reduced GLUT4 expression and membrane translocation in skeletal muscle and liver cells as well as in adipose tissue (70, 71)

For men already on testosterone therapy, tirzepatide may support weight loss, reduce abdominal fat, and improve hormone balance by lowering the amount of testosterone converted into estrogen through fat tissue