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The group of healthy women with the highest TMAO increase within 10 years had a 58% increased risk of coronary heart disease (RR 1.58), while those with sustained high TMAO had the highest risk (RR 1.79) (131)

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Consequences of dehydration on GLP-1s : Worsened nausea and constipation Fatigue and headaches Kidney stress Reduced weight loss (dehydration mimics hunger) Target : 2-3 liters (64-96 oz) of water daily , more if exercising or in hot weather

Rights and permissions About this article Cite this article Farhat, Z., Hershberger, P.A., Freudenheim, J.L

Early medications that simply boosted natural incretin levels had limited effectiveness because the hormones still degraded quickly

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