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Supplementary Figure 2 Inter-sample diversity (beta-diversity) analysis of healthy and OSCC oral microbiome considering the smokeless tobacco consumption status and sampling sites

The effects of nicotine pouches and E-cigarettes on oral microbes: a pilot study

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FDA over-regulation

This aligns well with the concept of Anna Karenina principle for animal microbiomes (Zaneveld et al., 2017), which refers to a more variable microbial community composition in dysbiotic individuals compared to healthy individualsparalleling Leo Tolstoys dictum that all happy families look alike

Vaping Vaping avoids burning tobacco, reducing exposure to toxins like tar and carbon monoxide