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Some lean mass reduction occurs during any meaningful weight loss but this is better understood as adaptive body remodeling , not muscle wasting. Lets unpack what the science shows

Keywords: exendin-4, liraglutide, hypodipsia, thirst glucagon-like peptide-1 (GLP-1) is produced primarily by L-cells in the intestine and neurons in the nucleus of the solitary tract (NTS) of the hindbrain in response to nutrient entry in the gastrointestinal tract (22, 27, 28)

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How these medications cause weight loss when combined is still somewhat of a mystery, but experts theorize that the combo touches the brains reward centers: Bupropion affects the pathways of two neurotransmitters, dopamine and norepinephrine, which are used in brain areas that process appetite and reward, and naltrexone tends to boost and reinforce this effect, Maselli says