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Clinically, it has been FDA-approved for the reduction of excess abdominal fat in HIV-positive patients with lipodystrophy, validating its potency as a metabolic agent

Genetic variations on redox control in cardiometabolic diseases: the role of Nrf2

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209,210,211 Taken together, these data strongly suggest that the effects of eNAMPT, as a cytokine, are independent of NAMPT enzymatic activity

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