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In particular, the interaction of ROS with NO, which is the best characterized (and likely most important) mediator of endothelial function, is felt to have an important role in determining the causal relationship between oxidative stress and hypertension

free copper ions in high local concentration can be pro-oxidant rather than antioxidant

Rosadini G, Marenco S, Nobili F, et al

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This condition can lead to inflammation and insulin resistance, both of which are associated with weight gain and obesity

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