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IQOS is the first and only tobacco heating system that the US Food and Drug Administration (FDA) has classified as a modified risk product, concluding that exposure to harmful substances when using this device is significantly reduced compared to cigarettes

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Employers who work in heavily THS-contaminated environments, such as casinos where indoor smoking is permitted, can be exposed for months or even years. Fortunately, the changes in the mitochondria of human keratinocytes exposed to nicotine for 24 hours are reversible