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Acetaldehyde, a component of cigarette smoke and metabolic product of alcohol breakdown, has epigenetic and genetic toxic effects (Shukla and Lim, 2013) and can inhibit key mitochondrial reactions and functions ( High levels of these reactive aldehydes form adducts on macromolecules present in the lungs, leading to an inflammatory response

Ito S, Ingenito EP, Brewer KK, Black LD, Parameswaran H, Lutchen KR, Suki B (2005) Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling

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Effect of Volatile Organic Compounds on Intestinal Microbiota Cigarette smoke contains large amounts of toxic volatile organic compounds (VOCs), such as isoprene, acrylonitrile, 1, 3-butadiene, acrylonitrile, styrene and benzene, which are inhaled into respiratory tract and induce different diseases, such as respiratory and cardiovascular diseases, and cancers (Pazo et al., 2016)