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FIGURE 10 The excipients only exert their activity at high concentration, which means that, while they are able to prevent proteolysis as soon as they are released from the capsule, peristaltic action and dilution with luminal fluid result in reduction of their inhibitory activity after a certain time windowprobably no longer than 30 minutes

10 The different cell types in the islets are known to be able to influence each others activity via paracrine communication, and additionally, they can regulate their activity via autocrine feedback