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However, the diagnosis and treatment of patients with long COVID to date has made it very clear that the majority of patients experience a multi-system syndrome characterized by fatigue with post-exertional malaise, cognitive deficits, depressed mood, stress-related head and joint pain, insomnia and vegetative dysfunction [99]

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For instance, a meta-analysis has demonstrated a notable reduction in C-reactive protein (CRP) levels following GLP-1RA therapy in individuals with T2DM [74]

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Autoimmune patients already have an elevated baseline risk for developing additional autoimmune conditions (a phenomenon called polyautoimmunity), which means they should be particularly vigilant about new symptoms while on tirzepatide