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Additionally, under section 910 draft guidance of the FD&C Act, 29 HPHCs have been outlined in the Premarket Tobacco Products Applications (PMTA) guidance for Electronic Nicotine Delivery Systems (ENDS)

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Tobacco use remains a leading cause of preventable mortality globally, accounting for approximately 8.71 million deaths annually, with the highest age-standardized rates observed in low- to middle-income countries [8]

Following the manufacturers instructions is important