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doi:10.1148/radiol.13122803

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10.2174/1566524017666171106112131 105 SheC.ShangF.CuiM.YangX.LiuN

From the outset, researchers identified a major obstacle to its use in pharmacological research: its extremely short plasma half-life (minutes) due to rapid capture by the six IGFBP 1-6 binding proteins present in human plasma