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Nicotine in cigarettes relaxes the LES (Lower Esophageal Sphincter), thereby allowing stomach acid to move back into the esophagus where it does not belong

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The data on snus is clearest, and in the European review, [33] which seemed motivated to emphasize any evidence for on-ramp effects, concluded, The Swedish data do not support the hypothesis that smokeless tobacco (i.e., Swedish snus) is a gateway to future smoking. [33]

Nicotine acts on specific receptors in the brain called nicotinic acetylcholine receptors (nAChRs), located in areas of the brain that influence reward, memory, attention, and learning

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2.Fiore MC, Jan CR, Baker TB, Bailey WC, Benowitz NL, Curry SJ, et al