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These trials included individuals with obesity or overweight with at least one weight-related condition, such as hypertension or dyslipidemia, and showed that semaglutide was significantly more effective than placebo and other comparators

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In addition, dietary datawhich critically influence gut microbiotawas not collected

Contact your trial team or GP promptly if you are unable to maintain adequate fluid intake

In the SURPASS-EARLY trial, nearly 800 adults diagnosed with type 2 diabetes within the past four years whose disease was not adequately controlled with metformin, diet and exercise were assigned to add either tirzepatide or other medications

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