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In rare cases where the result is unexpected, we explain the next steps clearly and arrange appropriate onward care
Change history 26 August 2025 The original online version of this article was revised: Author name Sungsoon Fang has been corrected
In colorectal cancer, targeting METTL3 reprograms the TME by lowering pro-tumor chemokines (CXCL1, CXCL5, CCL20) and enhancing antitumor responses, consistent with a METTL3chemokine axis that favors myeloid recruitment and immune evasion
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