IL-6 initiates many pro-inflammatory processes and regulates the expression of C-reactive protein (CRP), a marker of inflammation in COPD 39
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It also narrowed losses in its e-cigarette arm by 56.7% to 138 million
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To investigate this putative lineage relationship, we targeted the POU2F3 and FOXI1 TF genes, required for tuft cell 19 and ionocyte specification, respectively 17,19 , using CRISPR/Cas9 KO in human tracheal basal cells ( n = 5 donors, Supplementary Fig