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Rita DiLeo , D.Sc

FIGURE 3 A protein complex composed of ASC receptors and caspase-1 drives the pro-inflammatory cytokines IL-1 and IL-18, and cleaves Gasdermin D to induce programmed hepatocyte death ( Human Hep:KC cocultures: a model of the effect of inflammation on cytochrome P450s in hepatocytes A coculture model was developed by combining innate immune components to overcome the inherent limitations of hepatocyte single-culture systems such as KCs

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