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This signal tells your body to begin burning fat for fuel, a state often associated with metabolic flexibility

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

Couto N, Schooling SR, Dutcher JR, Barber J

& Bell, M

reported that cystine starvation impairs GPX4 protein expression by inhibiting mTORC1/4E-BP1-mediated protein translation 11

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