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BMJ 1994, 309: 901

Warning signs of a serious physical complication or fatal event after MDMA use include: Excessive thirst and profuse sweating Muscle cramping Shaking chills Blurred vision Fainting Seizures These signs can lead to liver, kidney, or heart failure

Notably, in vitro studies report that clofazimine also inhibits CYP2C8, CYP2D6, and CYP3A4/5, indicating the likelihood of clinically significant interactions with drugs metabolised by these isoenzymes (Lamprene, 2019

That's problematic, researchers say, because while normal cigarette smoke may contain more toxicants, recent evidence suggests e-cigarette clouds can still expose bystanders to nicotine, heavy metals, ultra fine particulates, volatile organic compounds, and other toxicants