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L'encapsulation de la Gemcitabine peut tre optimise en jouant sur les paramtres suivants : - Augmentation de la concentration de solution de dpartThe encapsulation of Gemcitabine can be optimized by playing on the following parameters: - Increasing the concentration of starting solution - Plusieurs cycles d'imprgnation- Several impregnation cycles - Diffrents temps d'imprgnation- Different impregnation times - Utilisation de diffrents solides avec une plus grande capacit (MILlOl biphenyl, MIL88D modifie avec diffrents groupes organiques) et de solides hybrides avec des ligands modifies (NH2, Cl, NO2, CH3, COOH, etc) pour optimiser les interactions mdicament- solide - En fonction des rsultats d' encapsulation, nous utiliserons des nanoparticules de solides modifis en surface avec du PEG pour des tests d' encapsulation.- Use of different solids with greater capacity (MILlOl biphenyl, modified MIL88D with different organic groups) and hybrid solids with modified ligands (NH2, Cl, NO2, CH3, COOH, etc.) to optimize drug-solid interactions - Depending on the encapsulation results, we will use surface modified nanoparticles with PEG for encapsulation tests