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Here's a quick breakdown of how GLP-1 works: Boosts insulin: The hormone encourages your pancreas to release more insulin, especially after a meal, which helps lower blood sugar

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Change history 26 August 2025 The original online version of this article was revised: Author name Sungsoon Fang has been corrected

So it follows that continuing treatment helps preserve weight loss over time. Mir Ali, MD In the other placebo-controlled trial, SURMOUNT-MAINTAIN, the researchers investigated the efficacy and safety of maximum tolerated dose (MTD) tirzepatide and a lower 5 milligram (mg) dose for maintaining body weight reduction in adults with obesity