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In this study, there was no significant PRS-smoking interaction for lung cancer
Nicotine has known pathological effects, mainly related to the excessive release of catecholamines, endothelial dysregulation and increased insulin resistance.90 Nicotine in electronic cigarettes has been shown to increase heart rate after overnight abstinence.91 Regarding lipid metabolism, nicotine in electronic cigarettes has been shown to increase the amount of circulating saturated fatty acids, decreasing the content of unsaturated fatty acids and inducing insulin resistance
Acknowledgements This work was supported by the National Institutes of Health (HL-105649 to J.T., HL-137004 to D.J.K
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