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Last Published 07.01.2026 Effective Date: 07.01.2026 This policy addresses the use of Itvisma (onasemnogene abeparvovec-brve) for the treatment of spinal muscular atrophy (SMA)

Lingzhi Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

6 males and 12 females)

Obesity Coverage: A Divided Perspective Obesity affects over 40% of adults in the United States and has been recognized as a chronic disease by the American Medical Association since 2013

It allows the body to adjust while progressively increasing the metabolic benefits

International regulatory responses further validate these concerns the European Medicines Agency required gastroparesis warnings before the FDA, while Health Canada issued safety communications about GLP-1 gastrointestinal risks, demonstrating global recognition of this serious adverse effect