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There are at least nine nAChR subunit types (27, 24) known to be expressed in the human brain, most of which were linked to smoking behavior-related phenotypes such as ever smoking (vs never), smoking quantity (measured as number of cigarettes per day (cig per day)), nicotine addiction, and tobacco use disorder through common (MAF 1%) variant-based genome-wide association studies (GWAS) 9,10,11,12,13

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