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However, GLP1/E reduced testosterone levels in PNA mice, an effect mimicked by monotherapies and metformin (Fig

Kisspeptin stimulates release of gonadotropin-releasing hormone (GnRH) and, in turn, GnRH stimulates release of luteinising hormone (LH) and follicle-stimulating hormone (FSH), ultimately causing the surge of LH which triggers ovulation

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Other GLP-1 agonist compounds tested in the study are liraglutide, dulaglutide, and exenatide, as well as tirzepatide that mimics a second intestinal hormone, gastric inhibitory polypeptide, or GIP, in addition to GLP-1