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Perhaps on a fishing shore excursion or even in Alaska when people may want to bring home some fresh salmon packed on ice

Toxicokinetics of Cyanide in Rats, Pigs and Goats after Oral Dosing with Potassium Cyanide

[193] On average a regular cigarette contains 628 mg of nicotine or the user will inhale about 1.1 to 1.8 mg of nicotine if just a portion is used

Then they injected the mice with cocaine and compared their behaviors with drugged mice that had not gotten the nicotine

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Heart: No organ except for the lungs is more affected by smoking than the heart and its circulation